Coffee: Bugs and Debugging

Coffee can bug or de-bug you - in many different ways.

It can actually energize your gut bugs. Nestlé researchers showed that for sixteen healthy adult volunteers consuming a daily dose of 3 cups of coffee during 3 weeks. This led to an increase of the metabolic activity and/or numbers of Bifidobacterium species, important probiotics in the food industry. Bifidobacteria has been long suggested to be therapeutic for the relief of intestinal disorders, including Irritable Bowel Syndrome (IBS). These microbes can crowd out the bad bacteria and fight inflammation. Does it mean coffee can alleviate IBS?

Unfortunately, no one was ever able to cure IBS with coffee. And diets lowering the amounts of bifidobacteria (like low FODMAP diet) are actually most beneficial for conditions associated with bacterial imbalance. Even though Bifidobacterium infantis 35624 was shown to help women at a dosage of 1x10⁸ CFU  for 4 weeks (but not 10⁶ or 10⁸ CFU!) with abdominal pain, bloating, gas, diarrhea, constipation and other IBS symptoms. And B. lactis DN-173 010 helped healthy women to reduce transit time when 10¹⁰ CFU of these bacteria was taken for 10 days.

RNA-DGGE gels of fecal samples showing abundance
and/or metabolic activity of dominant bacteria
before and after coffee consumption

Too much of a good thing can be a problem and it's important to keep even "good" bacteria at bay. How much is too much coffee for IBS sufferers? It depends. And it varies from being able to only smell coffee (which might be enough to protect from stress and cavities) to drinking two cups per day.

Everything is relative. That's why Aurametrix computes tolerance profiles based on many different factors - time of the consumption relative to wake up and bed times, diet an hour, week and month prior to consumption, medications and supplements, activity, gender, medical history, stress levels, the weather and genetics.

General recommendation for healthy people is to limit their coffee intake to about 4 or 3 cups - for men and women respectively.  To prevent insomnia, digestive issues, a racing heart, high blood pressure, nervousness, irritability, nausea, risk of developing glaucoma and other short & long term problems. And it's best to drink coffee in the first half of the day - as caffeine's half life is 5 hours or more, longer with unhealthy diet and medical conditions (it could be up to 7 days for people with alcoholic hepatic disease!). The worse your coffee metabolism is, the less you should drink it. Genetically-slow caffeine metabolizers (individuals homozygous for the  CYP1A2*1A allele in their genes) should actually limit coffee to 1 cup or less, to reduce the risk of myocardial infarction. Rapid caffeine metabolizers with CYP1A2*1F genotype, on the other hand, could reduce their heart failure risk by moderate consumption of coffee. Coffee could help mice avoid skin cancer - but only if they are also vigorously exercising. It can prevent reoccurence of breast cancer - if you already had it and are taking tamoxifen. With the right genes, bacteria, diet, activities and the brain gut axis, moderate amounts of coffee can also decrease risks of type 2 diabetes,  depression, workplace apathy, cognitive decline, gout attacks, respiratory disease, infections, stroke, injuries and accidents.

But these are statistical averages. And you are not average. You are unique and paradoxical in your own wonderful way. Aurametrix was created to help you understand that.

What is your Coffee worth?

REFERENCES

Jaquet M, Rochat I, Moulin J, Cavin C, & Bibiloni R (2009). Impact of coffee consumption on the gut microbiota: a human volunteer study. International journal of food microbiology, 130 (2), 117-21 PMID: 19217682

Cornelis, MC et al., 2006. Coffee, CYP1A2 genotype, and risk of myocardial infarction. J. Amer. Med. Assn. 295(10):1135-1141.

Nehlig A: The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. Br J Clin Pharmacol 2013, 75:716–727.

Lucas M, Mirzaei F, Pan A, Okereke OI, Willett WC, O'Reilly ÉJ, Koenen K, Ascherio A: Coffee, caffeine, and risk of depression among women. Arch Intern Med 2011, 171:1571–1578

Jin JS, Touyama M, Hisada T, Benno Y: Effects of green tea consumption on human fecal microbiota with special reference to Bifidobacterium species. Microbiol Immunol 2012, 56:729–739.

Maria Simonsson, Viktoria Söderlind, Maria Henningson, Maria Hjertberg, Carsten Rose, Christian Ingvar, Helena Jernström. Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status. Cancer Causes & Control, 2013; 24 (5): 929 DOI: 10.1007/s10552-013-0169-1

Tzounis X, Rodriguez-Mateos A, Vulevic J, Gibson GR, Kwik-Uribe C, Spencer JP: Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr 2011, 93:62–72.

Mostofsky E, Rice MS, Levitan EB, Mittleman MA. Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis.  Circ Heart Fail. 2012 Jul 1;5(4):401-5. doi: 10.1161/CIRCHEARTFAILURE.112.967299. Epub 2012 Jun 26.

Gabashvili, I. Why red beans and rice are good.. but not with coffee. Forbes, 4/30/2012

Molehills and Mountains

If you suffer from IBS, chances are you're very considerate of others and even possibly an anxious ''catastrophizer.'' It was repeatedly concluded based on magnetic resonance imaging of the brain and psychological questionnaires -  for students and non-students, Easterners and Westerners, right-handed and left-handed individuals. In fact, IBS sufferers' anxieties are somewhere in between those of people with Crohn's disease (similar to healthy persons) and panic patients. And many IBS sufferers are convinced that social and occupational implications of their gastrointestinal symptoms are a catastrophe.

As someone once said, catastrophizing is not just about watching slow German films or reading Russian literature and feeling as though life is an intolerable and senseless joke. If practiced properly, catastrophizing could make many things go wrong and create a reality around our worries and fears. Including fears focused on the gut. Because if you believe something will go wrong, you make it go wrong.

But is it the personality that makes us susceptible to IBS or is it IBS that changes our personality? The connection between the brain and the gut is definitely bidirectional. So this question might be a chicken-and-egg problem.

Animal studies suggest that perturbations of behavior, such as stress, can alter microbial communities in the gut. Experimental perturbation of the microbial communities, in its turn, can alter behavior. Getting rid of some microbes helped mice to reduce anxiety or even become bold and adventurous (after neomycin, bacitracin, and pimaricin antibiotics were administered to timid and shy BALB/c mice), while adding new species of bacteria such as Campylobacter jejuni  made mice more cautious.

Many recent studies indicate the possibility of discovering bacteria specific for different types of IBS. But you can make your own discoveries before science does. Such as the best diet, exercise and emotional attitude to cultivate the bacteria of success.


Your result will be the last one in the table below. It might take up to 24 hrs for it to appear so please come back to see it.
Your score is represented in three dimensions:
rumination (repetitiveness of focusing on the symptoms of distress), magnification (the degree to which you tend to magnify your symptoms) and hopelessness (the despair you feel when you have abandoned hope of comfort or success).

REFERENCES


Hazlett-Stevens H, Craske MG, Mayer EA, et al. Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety. J Psychosom Res 2003;55:501–505.

Ng SM, Chow KW. Symptoms catastrophizing versus social hypervigilance in irritable bowel syndrome patients. Soc Work Health Care. 2012;51(8):743-56. doi: 10.1080/00981389.2012.701001.

Hunt MG, Moshier S, Milonova M. Brief cognitive-behavioral internet therapy for irritable bowel syndrome. Behav Res Ther. 2009 Sep;47(9):797-802. Epub 2009 May 20.

Eric L. Garland, Susan A. Gaylord, Olafur Palsson, Keturah Faurot, J. Douglas Mann and William E. Whitehead Therapeutic mechanisms of a mindfulness-based treatment for IBS: effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations. Journal of Behavioral Medicine, 2011, Dec. 8

Blankstein U, Chen J, Diamant NE, Davis KD. Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors.
Gastroenterology. 2010 May;138(5):1783-9. doi: 10.1053/j.gastro.2009.12.043. Epub 2010 Jan 4.

Collins SM, Surette M, & Bercik P (2012). The interplay between the intestinal microbiota and the brain. Nature reviews. Microbiology, 10 (11), 735-42 PMID: 23000955

Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil. 2011 Mar;23(3):255-64, e119. doi: 10.1111/j.1365-2982.2010.01620.x. Epub 2010 Nov 5.

Collins SM, Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology. 2009 May;136(6):2003-14. doi: 10.1053/j.gastro.2009.01.075. Epub 2009 May 7.


Goehler LE, Park SM, Opitz N, Lyte M, Gaykema RP. Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior. Brain Behav Immun. 2008 Mar;22(3):354-66. Epub 2007 Oct 24.

Sullivan MJL, Bishop S, Pivik J. The Pain Catastrophizing scale: development and validation. Psychol Assess 1995;7:524–32. (the manual)

Carbohydrates for your bacteria

Our bacteria are picky eaters. Some of them - like Prevotelia - prefer a high carbohydrate diet, while others - like Bacteroides - stick to unhealthy western lifestyle with lots of meat and fat. The most prevalent bacteria in the gut of horses, cows and goats prefer people consuming alcohol and polyunsaturated fats. Methanobrevibacter is most abundant in anorexic nervosa patients. Gram negative bacillus Bilophila wadsworthia loves people with gangrenous appendicitis or those whose diets are high in milk fat. The most widely promoted prebiotics inulin and fructooligosaccharides seem to attract Bifidobacteria. What about diets low in poorly absorbed fermentable carbohydrates aka FODMAPs that seem to aggravate irritable bowel syndrome (IBS) ? Which bacteria is responsible?

A recently completed clinical trial  looked at the effects of low-FODMAP dieting by analyzing Short Chain Fatty Acids (SCFA), pH and other qualities of stool.

The data show that with less FODMAPs in the diet, there seemed to be less water and fermentable substances in the proximal colon, and less gastrointestinal distress in patients with IBS. This randomized controlled trial also demonstrated a reduction in concentration and proportion of luminal bifidobacteria after 4 weeks of fermentable carbohydrate restriction.

Bifidobacteria? Isn't it one of the "friendliest" bacteria alleviating symptoms in IBS, by normalizing the ratio of an anti-inflammatory to proinflammatory cytokines? At least, as was shown for B.infanitis 35624 and B. animalis DN-173 010 in different studies. It looks like that the most effective species and the implications of diets on the gastrointestinal microbiota are still uncertain. After all, another study showed that even though IBS sufferers have lower amounts of Bifidobacteria than non-sufferers, those whose symptoms are less severe show even lower amounts of Bifidobacteria in their samples.

What can we say except that more studies are needed...

REFERENCES

Staudacher HM, Lomer MC, Anderson JL, Barrett JS, Muir JG, Irving PM, & Whelan K (2012). Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. The Journal of nutrition, 142 (8), 1510-8 PMID: 22739368

Suzanne Devkota, Yunwei Wang, Mark W. Musch, Vanessa Leone, Hannah Fehlner-Peach, Anuradha Nadimpalli, Dionysios A. Antonopoulos, Bana Jabri, Eugene B. Chang. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice. Nature, 2012; DOI: 10.1038/nature11225

Cui S, & Hu Y (2012). Multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. International journal of clinical and experimental medicine, 5 (3), 238-44 PMID: 22837798

Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD, & Lewis JD (2011). Linking long-term dietary patterns with gut microbial enterotypes. Science (New York, N.Y.), 334 (6052), 105-8 PMID: 21885731

O'Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, O'Sullivan GC, Kiely B, Collins JK, Shanahan F, Quigley EM. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology. 2005 Mar;128(3):541-51.

Finding the Goldilocks Solution

A top story in today’s news is related to a recent scientific paper published in Current Biology concerning the dinosaurs. British scientists wanted to know, Could methane produced by sauropod dinosaurs have helped drive Mesozoic climate warmth?  By their estimates, some 520 million tons of methane (a “greenhouse gas” emission) were produced by the flatulent beasts every year.  This begs the question, do flatulent humans today also contribute to global warming?

Probably not enough to be concerned about. Even so, this doesn’t allay the anxieties people have about expulsing gas—anxieties that have more to do with interpersonal relationships in the workplace than with the implications of global warming.

As Dr. Wynne-Jones says in an article on diverticular disease, many bowel-related problems are in fact confined to modern urban communities affecting “the cultured, the refined, the considerate.” Folks go out of their way to avoid beans in their diet for fear of embarrassing themselves in a working environment where everyone is packed together in neighboring cubicles.

Happily, Winham  and  Hutchins discovered that over 50% of people can consume up to ½ cup of beans daily without any adverse effects. But how do you know how much beans to eat on your own?  How do you arrive at the Goldilocks amount—not too much, not too little—that’s just right for you?

Personal health analysis tools like Aurametrix are already making it possible to apply systematic measures to discover for ourselves our individual tolerance levels for a wide variety of foods. As Aurametrix founder Irene Gabashvili remarked in her Forbes article:  “A digital nurse can analyze hundreds of ‘health variables’ in search of patterns in the data. She could do this with far greater precision than a physician or nutritionist, due to her ability to quickly and tirelessly check all possible combinations. In a relatively short timeframe she could narrow down the factors that are positively and negatively influencing your health, while taking into consideration your pre-existing conditions and sensitivities.”

To see the digital nurse in action, see the video below. It shows how to pin-point the causes of a related, though potentially embarrassing, physiological process: frequent stomach growling.

REFERENCES

• Wilkinson, D., Nisbet, E., & Ruxton, G. (2012). Could methane produced by sauropod dinosaurs have helped drive Mesozoic climate warmth? Current Biology, 22 (9) DOI: 10.1016/j.cub.2012.03.042 
• Winham DM, & Hutchins AM (2011). Perceptions of flatulence from bean consumption among adults in 3 feeding studies. Nutrition journal, 10 PMID: 22104320
• Wynne-Jones, G. (1975) Flatus retention is the major factor in diverticular disease. The Lancet, 306 (7927), 211 - 212, doi:10.1016/S0140-6736(75)90677-7

Adding red to your diet

We are always happy receiving nice e-mails from users. Here is a recent letter:

Dear Aurametrix,

I would like to share with you some interesting results that really surprised me, even though they're a little embarrassing. 

I've been using Aurametrix now about 2 months but mostly on days when I experience a symptom (2 entries for diarrhea).  So about 20 entries in all, including food, a few feeling good plus these symptoms:

Diarrhea, experienced 1 bout around 2:30 PM PDT on September 18, 2011

Diarrhea, experienced 1 bout around 3:30 PM PDT on October 30, 2011

I did an analysis on the second day: Diarrhea relative to Feeling Good, 12 hours 

These are the results copied from the tool:

Based on your Aura entries, the following may be contributing to "Diarrhea" in a 12 hour timeframe:

• Lycopene (when consumed more than 5.9 micrograms, up to 2650.6)
• Orange or Yellow fruits and veggies (when consumed more than 0.1 foods, up to 1.0)

I looked up lycopene and it's a chemical in orange-colored fruits. It so happens that I ate mango one day and a raw papaya on the other day I experienced the symptoms. I think I will avoid these fruits in the future (I haven't had any since I learned about it from Aurametrix)

You can post this if you want since I think it's worthwhile to let other people know that the tool really works and I don't have symptoms.

Regards,

Aurametrix User :)

Lycopene is a carotenoid, a pigment that gives fruits and vegetables a red color. It is found in some red, pink, orange and yellow fruits and vegetables such as tomatoes (especially skins), watermelons, grapefruits, apricots, papayas, and guavas.

Lycopene is an antioxidant, but in the human body it converts into lycopenoids with the help of carotenoid monooxygenase (CMO) enzymes. Lycopene metabolism depends on the person. It is more efficient in those with more active CMOs, higher testosteron and those not restricting dietary intake.

A number of studies have suggested that a higher intake of lycopene-containing foods decreases the risk of heart disease, prostate cancer, other cancers and infections, even cataracts and asthma. Lycopene is thought to prevent male infertility, osteoporosis, varicose veins and eye disease. Lycopene may also reduce or prevent the side effects of chemotherapy.

What are the potential side effects? In one Mayo Clinic study (Jatoi et al, 2007), the most common side effect for patients who took 15,000 micrograms of lycopene twice per day was diarrhea (41% of patients), followed by nausea (26%), abdominal distension (17%), and flatulence (4%).


The same effects were also observed by IBS sufferers - like this case of massive diarrhea from fresh tomato on a sandwich or this bad gut reaction to tomato sauce. Mangoes and Papayas are usually considered safe for IBS, yet occasional incidents are posted on the web.

So, should you limit your Lycopene intake if Aurametrix indicates it may cause your diarrhea? Take a note about it and keep analyzing your diet. Analyses that start from "Aura entries" examine food combinations and will tell you if there is something that negates the effect. Perhaps there was a day when you ate it and felt OK. You might not remember it, but Aurametrix will.

REFERENCES

Jatoi A, Burch P, Hillman D, Vanyo JM, Dakhil S, Nikcevich D, Rowland K, Morton R, Flynn PJ, Young C, Tan W, & North Central Cancer Treatment Group (2007). A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II study from the North Central Cancer Treatment Group. Urology, 69 (2), 289-94 PMID: 17320666.

Kelkel M, Schumacher M, Dicato M, Diederich M. (2011) Antioxidant and anti-proliferative properties of lycopene. Free Radic Res. 2011 Aug;45(8):925-40. Epub 2011 May 26.

Brian L. Lindshield, Kirstie Canene-Adams, John W. Erdman Jr (2007) Lycopenoids: Are lycopene metabolites bioactive? Archives of Biochemistry and Biophysics. Volume 458, Issue 2, Pages 136-140.